The School of Geosciences at Wits University recently launched the Wits Isotope Geoscience Laboratory (WIGL), a state-of-the-art, ultra-clean (Class 10-100), metal-free laboratory designed to perform chemical separation and isotope dilution on samples destined for isotope mass spectrometry. Besides traditional chemical isotopic techniques (Sr, Nd, Hf, Pb, U-Th), non-traditional stable isotope techniques (e.g. Fe, Cu, Ca, Be) have also been developed in an environment designed to reduce background or blank concentrations to the lowest level possible. As an illustration of the cleanliness of the  air supplied to the metal-free laboratory space is filtered multiple times, reducing the contaminating particle count from well-over 1 million particles per cubic foot to between 10 particles in the cleanest work areas. The WIGL is as a multi-user facility (up to five users simultaneously) for interdisciplinary research and will be able to process a range of sample materials including rocks, fossils, archaeological artefacts, water samples and biological material. The chemically processed samples can be analyzed using a mass spectrometer at the newly installed NuPlasma MC-ICPMS laboratory at the University of Johannesburg (UJ), through a strong collaboration with the Wits Isotope Geoscience Laboratory, or through a network of global collaborations including TIMS instruments.